- The region’s two major U.S. highways, Routes 29 and 460, connect businesses with other regional assets and nearby metropolitan areas and transit hubs, including Roanoke, Richmond, and The Port of Virginia in Hampton Roads.
- Lynchburg is 55 miles from Interstate 81, the longest interstate in Virginia that provides access to north/south destinations, and 65 miles from Interstate 64, connecting the region to destinations to the east and west.
- CSX Transportation and the Norfolk Southern Railway Company provide freight rail service to area businesses.
- Passenger rail service is provided by Amtrak, with daily round-trip commuter service to Washington, D.C., and servicing cities northbound to New York and southbound to New Orleans.
- Two regional airports provide general aviation services, and the Lynchburg Regional Airport (LYH) offers direct commercial air service to the international air hub at Charlotte Douglas International Airport through American Airlines’ American Eagle regional affiliate.