- Interstates 66 and 81 run through the region and provide easy access to markets along the Eastern Seaboard and the Midwest.
- Eight additional interstates are 42 miles or less from the region: I-68 (14 miles), I-70 (18 miles), I-270 (27 miles), I-370 (33 miles), I-495 (36 miles), I-76 (36 miles), I-99 (41 miles), and I-95 (42 miles).
- Freight rail service is provided by CSX Transportation, linking to Norfolk Southern.
- The Virginia Inland Port (VIP), an intermodal container transfer facility, is located in the region, and The Port of Virginia in Hampton Roads is 204 miles southeast.
- Two regional airports provide general aviation services, and Washington-Dulles International (IAD) offers commercial flights and cargo transportation less than 40 minutes from Frederick County.
- Ronald Reagan Washington National Airport (DCA) and Baltimore-Washington International Airport (BWI) offer additional options in less than two hours.